The actor who appears as Spock in the new Star Trek movies and who also starred in TV's Heroes, made the revelation in a new interview about his work on Broadway.
Quinto, 34, won raves in Angels in America, a revival of the Pulitizer Prize-winning play set in the early days of the AIDS epidemic.
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It was “the most challenging thing I’ve ever done as an actor and the most rewarding” he told New York magazine.
"And at the same time, as a gay man, it made me feel like there’s still so much work to be done, and there’s still so many things that need to be looked at and addressed.”
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Quinto has played numerous gay roles in the past and has been active in gay causes but he's never previously addressed his own sexual orientation.
He played a gay character on Tori Spelling’s TV show So NoTORIous, and another on the new F/X series, American Horror Story.
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In the interview, Quinto took a look at the growing number of states where gay marriage is now legal while at the same time gay teens are being bullied to the point of committing suicide.
"As a gay man I look at that and say there’s a hopelessness that surrounds it, but as a human being I look at it and say ‘Why? Where’s this disparity coming from, and why can’t we as a culture and society dig deeper to examine that?’ We’re terrified of facing ourselves.”
Quinto's next movie is the financial thriller Margin Call, opening Friday.